Effects of progestin-only contraceptives on the phenotype and function of female reproductive tract CD4+ and CD8+ T cells
نویسندگان
چکیده
Methods Participants using either DMPA (n=15) or the LNG iUS (n=19) for at least 3 months and women using no hormonal contraceptives (n=24) were recruited. Endocervical curettage, endocervical cytobrush, and endometrial biopsy were obtained from all women. Expression of T cell activation markers, memory/effector differentiation markers and HIV co receptors were assessed by multiparameter flow cytometry. CD4+ and CD8+ T cells producing CD107a, IL-10, IL-2, IFNg, MIP1b and IL-17 were measured after stimulation with PMA/ionomycin or staphylococcal enterotoxin B (SEB).
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